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By Guy F. Webster, Anthony V. Rawlings

Addressing essentially the most often encountered stipulations visible by means of the dermatologist, this resource analyzes the pathophysiology, assessment, analysis, medical gains, and regulate of zits. With full-color illustrations, this resource delves into the on hand cures for tricky circumstances of zits and scarring and offers specialist discussions of administration regimens together with topical and systemic cures, laser remedies, and new medicines.

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Oxford: Oxford University Press, 1991:83 –89. 11. Westgate GE, Shaw DA, Harrap GJ, Couchman JR. Immunohistochemical localisation of basement membrane components during hair follicle morphogenesis. J Invest Dermatol 1984; 82:259– 264. 12. Millar SE. Molecular mechanisms regulating hair follicle development. J Invest Dermatol 2002; 118:216– 225. 13. McElwee KJ, Hoffman R. Growth factors in early hair follicle morphogenesis. Eur J Dermatol 2000; 10:341– 350. 14. Ebling FJG. Embryology. In: Rook A, Wilkinson DS, Ebling FJG, eds.

McElwee KJ, Hoffman R. Growth factors in early hair follicle morphogenesis. Eur J Dermatol 2000; 10:341– 350. 14. Ebling FJG. Embryology. In: Rook A, Wilkinson DS, Ebling FJG, eds. Textbook of Dermatology. Oxford: Blackwell Scientific, 1968:16– 22. 15. Ferraris C, Bernard BA, Dhouailly D. Adult epidermal keratinocytes are endowed with pilosebaceous forming abilities. Int J Dev Biol 1997; 41:491– 498. 16. Serri F, Huber WM. In Advances in Biology of Skin. Vol. 4. Oxford: Pergamon Press, 1963:1– 18.

In vivo, the presence of EGF inhibited the sebaceous gland differentiation in sheep (153), and in hamster ears, it stimulated the sebaceous glands to proliferate (154). Receptors for EGF are found in sebaceous glands (155). Based on this evidence, Kealey and colleagues proposed that EGF may be, in part, responsible for sebaceous gland atrophy observed during acne lesion formation (7,152). EGF can also induce changes in sebum composition. Ridden (156), reported that there was a fall in the amount of squalene and a corresponding rise in cholesterol, although this was not corroborated by other researchers (157).

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